QT-Screen

QT-Screen, from Multi-Channel Systems, is the worlds first fully automated system for high throughput QT prolongation screening.

It combines the advantages of superior extracellular recording and reliable data acquisition technology with standardized liquid handler technology.

Concentration series are generated automatically from 96 well compound plates.

Starting with the lowest concentration, 8 to 10 concentrations of 8 different compounds are tested in parallel and in replicates of 12.

Cultivation and measurement on the same device

The technique of using microelectrode arrays represent an innovative way to reveal action potential data from cardiac myocytes, cultivated directly on a chip. This method allows cultivation and recording on the same device.

Each well includes a recording/ stimulation and reference electrode. All materials are tested for excellent biocompatibility. After 2-3 days in culture, the cell cultures begin to beat spontaneously. The low cost of consumables insures low operating costs.

User friendly, flexible graphical interface

• Easy designing of recording sequences, and implementation of custom quality checks.
• Fluid delivery, realtime monitoring, and online dose response analysis are all computer controlled.
• Wide range of analytical tools available include algorithms for calculating corrected QT intervals and identifying tachycardia and bradycardia.
• Results are entered automatically into a standard database.